Fumarate exerted an antihypertensive effect and reduced kidney injury molecule (KIM)-1 expression in deoxycorticosterone acetate-salt hypertension

Autor:	Osaze Edosuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	fumarate hypertension l-arginine metabolism redox state tricarboxylic acid cycle Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Clinical and Experimental Hypertension, Vol 43, Iss 6, Pp 555-564 (2021)
Druh dokumentu:	article
ISSN:	1064-1963 1525-6006 10641963
DOI:	10.1080/10641963.2021.1916943
Popis:	Background: The tricarboxylic (TCA) acid cycle provides the energy needed for regulatory functions in the cardio-renal system. Recently, a genetic defect in the TCA cycle enzyme, fumarase hydratase, altered L-arginine metabolism and exacerbated hypertension in salt-sensitive rats. This study evaluated the effect of fumarate and its possible link to L-arginine metabolism in deoxycorticosterone (DOCA)-salt hypertension, a non-genetic model of hypertension.Method: Hypertension was induced with DOCA (25 mg/kg s.c, twice weekly) + 1% NaCL in uninephrectomised rats placed on fumarate (1 g/L, ad libitum). Blood pressure was measured in conscious rats via carotid cannulation. Biochemical and western blot analyses were carried out on kidney fractions.Results: Fumarate reduced mean blood pressure (198 ± 5 vs 167 ± 7 mmHg, p
Databáze:	Directory of Open Access Journals
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