Effects of Theabrownin on Brain Metabolites in D-galactose-induced Aging in Mice

Autor: Shuwen LEI, Guihua XIE, Zhifang ZHANG, Yue MIAO, Chunyan ZHAO, Dehong CHEN, Yan HOU, Jiashun GONG
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: Shipin gongye ke-ji, Vol 44, Iss 5, Pp 43-52 (2023)
Druh dokumentu: article
ISSN: 1002-0306
DOI: 10.13386/j.issn1002-0306.2022050204
Popis: The objective of the study is to investigate the effect of theabrownin on the immunohistochemistry of brain tissue in aging mice, screen the differential metabolites and analyze the metabolic pathways involved. A mouse aging model was established by subcutaneous injection of D-galactose in mice. Immunohistochemical and UHPLC-QE-MS metabolomics techniques were used to detect brain samples of normal control mice, D-galactose model mice and theabrownin-treated (pretreatment and treatment) mice. The results showed that the areal density of choline acetyltransferase positive expression was significantly increased (P
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