Urinary protein carbonyl levels and its correlation with protein misfolding in preeclampsia

Autor:	Chandrakala Nagarajappa, Sheela Shikaripur Rangappa, Ravishankar Suryanarayana, Sharath Balakrishna
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	preeclampsia protein carbonyl misfolded proteins Gynecology and obstetrics RG1-991
Zdroj:	Hypertension in Pregnancy, Vol 38, Iss 2, Pp 124-128 (2019)
Druh dokumentu:	article
ISSN:	1064-1955 1525-6065 10641955
DOI:	10.1080/10641955.2019.1590720
Popis:	Objective: To evaluate the association of protein carbonylation with preeclampsia and its correlation with urinary protein misfolding.Method: Protein carbonyl and misfolded protein levels were measured in the midstream urine sample (58 preeclamptic and 44 normotensive pregnancy) by ELISA and Congo Red Dot assay respectively.Results: Significant difference was observed in the levels of protein carbonyls (P = 0.002) and misfolded proteins (P = 0.001). Correlation between protein carbonyl and misfolded proteins levels was significant but weak (r = 0.3; P = 0.018).Conclusion: Urinary protein carbonyl level is elevated in preeclampsia but plays a minor role in proteins misfolding.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9d4aa2b64e76481cb6fef3e8369658fb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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