Role of Oct3/4 in Cervical Cancer Tumorigenesis
| Autor: | Sayuri Itzel Clemente-Periván, Yazmín Gómez-Gómez, Marco Antonio Leyva-Vázquez, Alfredo Lagunas-Martínez, Jorge Organista-Nava, Berenice Illades-Aguiar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Frontiers in Oncology, Vol 10 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2234-943X 06080065 |
| DOI: | 10.3389/fonc.2020.00247 |
| Popis: | Cervical cancer (CC) is the fourth most common type of cancer that affects women. Compared to other types of cancer, CC has a high mortality rate in women worldwide. Several factors contribute to the development of CC, but persistent high-risk human papillomavirus infection is the main etiologic agent associated with the development of CC. Moreover, several studies reported that alterations in the expression of transcription factors present in a small subpopulation of cells within tumors called cancer stem cells (CSCs), which contribute to the development of CC by promoting tumorigenicity and metastasis. These transcription factors affect self-renewal and maintenance of pluripotency and differentiation in stem cells. OCT3/4 belongs to the family of transcription factors with the POU domain. It consists of five exons and can be edited by alternative splicing into three main transcripts: OCT3/4A, OCT3/4B, and OCT3/4B1. The OCT3/4 expression in CSCs promotes carcinogenesis and the development of malignant tumors, and the loss of expression leads to the loss of self-renewal and proliferation and favors apoptosis. This review describes the main roles of OCT3/4 in CC and its importance in several biological processes that contribute to the development of CC and may serve as molecular targets to improve prognosis of CC. |
| Databáze: | Directory of Open Access Journals |
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