| Autor: |
Jianwen Liu, Chenmin Wu, Juanjuan He, Yanfang Wu, Fei Gao, Zhihan Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Rheumatology & Autoimmunity, Vol 3, Iss 2, Pp 100-107 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2767-1429 |
| DOI: |
10.1002/rai2.12074 |
| Popis: |
Abstract Background Accurate diagnosis of Pneumocystis jirovecii pneumonia (PJP) is challenging, and the delayed diagnosis of PJP is associated with high mortality in patients with connective tissue disease (CTD). Metagenomic next‐generation sequencing (mNGS) technology facilitates etiological diagnosis of various infectious diseases, with promising application in diagnosing PJP. This study aimed to investigate the value of mNGS using bronchoalveolar lavage fluid (BALF) for diagnosing PJP infection. Methods Data from 55 patients with CTD and suspected pulmonary infection was retrospectively collected and analysed. A PJP group and non‐PJP group were formed. The clinical manifestations, laboratory test results, treatment methods, and outcomes were summarized. BALF mNGS results were compared with traditional pathogen tests (TPT) and serum 1,3‐beta‐D‐glucan (BDG) testing. Results The mean age of PJP patients was 54 years, and 59% (10/17) of the patients were female. A significant difference was found between the average daily dose of prednisone administered to the PJP group and non‐PJP group (25 mg vs. 16 mg, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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