Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway

Autor: Hadeel M. Osama, Sally M. Khadrawy, EL-Shaymaa EL-Nahass, Sarah I. Othman, Hanaa M. Mohamed
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Laboratory Animal Research, Vol 40, Iss 1, Pp 1-16 (2024)
Druh dokumentu: article
ISSN: 2233-7660
DOI: 10.1186/s42826-024-00204-8
Popis: Abstract Background Thyroid hormones (THs) regulate growth, development and function of different tissues. Hypothyroidism is a common clinical disorder characterized by deficiency in THs and adversely affects the development and functions of several organs. This work aimed to investigate the ameliorative effect of eltroxin (ELT), a hypothyroidism medication, and hesperidin (HSP), a flavonoid, against testicular and renal toxicity in hypothyroid rats. Twenty-four rats were divided into four groups and treated orally for 12 weeks. Group I (control), group II (hypothyroidism) received 20 mg/kg carbimazole (CBZ), group III received CBZ and 0.045 mg/kg ELT, and group IV received CBZ and 200 mg/kg HSP. Results CBZ administration induced biochemical and histopathological changes in testis and kidney. Co-administration of ELT or HSP significantly (P
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