| Autor: |
Kai Wang, Chengfang Li, Yin Li, Jinjing Wang, Aiqing Ma |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Materials Research Express, Vol 7, Iss 10, p 105014 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2053-1591 |
| DOI: |
10.1088/2053-1591/abc21d |
| Popis: |
This paper applied hierarchy MoS _2 particles for near-infrared induced drug delivery towards liver cancer treatment. MoS _2 particles were used as the photothermal responsive agent, 1-tetradecanol was used as the phase change material, doxorubicin was encapsulated into the particles, and MoS _2 /1-tetradecanol@doxorubicin composite was synthesized. The drug release was tested under near-infrared irradiation. Within the MoS _2 /1-tetradecanol@doxorubicin composite, the photothermal response of MoS _2 to near-infrared facilitated the phase change of 1-tetradecanol and the release of doxorubicin. The release of doxorubicin could be regulated by both the MoS _2 concentration and the irradiation power. The cytotoxicity study indicated that MoS _2 /1-tetradecanol had negligible toxicity to the HepG2 cells, while MoS _2 /1-tetradecanol@doxorubicin had more tumor-killing effects than free doxorubicin. This research showed that hierarchy MoS _2 particles had the potential of delivering anti-tumor drugs through photothermal stimuli. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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