Treatment of pruritus in a palliative care patient with low-dose paroxetine: a case report

Autor: Roni Y. Kraut
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Medical Case Reports, Vol 11, Iss 1, Pp 1-3 (2017)
Druh dokumentu: article
ISSN: 1752-1947
DOI: 10.1186/s13256-017-1437-6
Popis: Abstract Background Pruritus is a distressing symptom seen in palliative care. There is limited high-quality evidence of pharmaceutical treatments for pruritus in palliative care, including the use of paroxetine. Case presentation I present a case of a 70-year-old caucasian woman with metastatic ovarian cancer who presented with severe pruritus. She had been diagnosed with bile duct obstruction 1 month earlier. Antihistamines and over-the-counter skin creams were first trialed, to no effect. Paroxetine was started at 5 mg in the evening, with the intention of titrating up. However, 5 mg of paroxetine was effective, and the patient’s pruritus fully resolved after the second day. Conclusions This case supports the use of paroxetine as a therapy for pruritus in palliative care patients and suggests that paroxetine may be effective at a very low dose.
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