Quantitative 1H Nuclear Magnetic Resonance Method for Assessing the Purity of Dipotassium Glycyrrhizinate

Autor:	Yuan-Yuan Zhang, Jie Zhang, Wen-Xuan Zhang, Yue Wang, Ying-Hong Wang, Qing-Yun Yang, Song Wu
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	qNMR dipotassium glycyrrhizinate methodology validation purity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 12, p 3549 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26123549
Popis:	A simple, rapid, accurate, and selective quantitative method based on 1H nuclear magnetic resonance (qNMR) was successfully established and developed for assessing the purity of dipotassium glycyrrhizinate (KG). In this study, using potassium hydrogen phthalate and fumaric acid as internal standard (IS), several important experimental parameters, such as relaxation delay and pulse angle, were explored. Reliability, specificity, linearity, limit of quantification, precision, stability, and accuracy were also validated. Calibration results obtained from qNMR were consistent with those obtained from HPLC coupled with ultraviolet detection. The proposed method, independent of the reference standard substance, is a useful, reliable, and practical protocol for the determination of KG and glycyrrhizin analogs.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9d2bccfca3e743859cf43fff7d2d996b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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