| Autor: |
Asmae Amirou, El Mahdi Razzok, Abdelkhaleq Legssyer, Abderrahim Ziyyat, Mohammed Aziz, Mohamed Bnouham, Younes Zaid, Mohamed Berrabah, Hassane Mekhfi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Advances in Pharmacological and Pharmaceutical Sciences, Vol 2023 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2633-4690 |
| DOI: |
10.1155/2023/5644803 |
| Popis: |
Thrombosis is the formation of a clot within a blood vessel. Antithrombotic drugs are used for treating thrombosis, which can be the cause of hemorrhage. Currently, there is a need to discover novel antithrombotic drugs. Walnut is widely used to treat a wide range of health complaints. In this study, walnut bark extract was tested in hemostasis parameters: platelets adhesion, aggregation, and plasmatic coagulation in human blood. The crude aqueous extract of walnut bark was prepared by infusion and tested in vitro on hemostasis. Through blood collection from healthy volunteer donors, we studied different parameters of the primary hemostasis: platelet adhesion on the collagen-coated surface under flow, ADP, collagen, thrombin, and arachidonic acid-induced platelet aggregation, and of the secondary hemostasis by measuring prothrombin time (PT) and activated partial thromboplastin (APTT) parameters. All experiments are realized in the absence and presence of the extract and repeated at least twice. The obtained data showed that the extract (1 and 2 mg/mL) significantly (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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