Quantitative Imaging of the Iron-Oxide Nanoparticle- Concentration for Magnetic Drug Targeting Employing Inverse Magnetomotive Ultrasound

Autor: Fink Michael, Lyer Stefan, Alexiou Christoph, Rupitsch Stefan J., Ermert Helmut
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Current Directions in Biomedical Engineering, Vol 5, Iss 1, Pp 417-419 (2019)
Druh dokumentu: article
ISSN: 2364-5504
DOI: 10.1515/cdbme-2019-0105
Popis: Magnetomotive Ultrasound is an imaging technique that is capable to detect tissue, which is perfused by magnetic nanoparticles. However, this modality is restricted to qualitative imaging only. Therefore, we present an extended Magnetomotive Ultrasound algorithm, which allows the quantitative determination of the spatial distribution of magnetic nanoparticle density in tissue. The algorithm is based on an iterative adjustment of simulated data to measurements. Experiments with tissue-mimicking phantoms reveal that the presented method leads to the spatial particle concentration in the correct order of magnitude.
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