Nitric oxide mediates interleukin-1 induced inhibition of glycosaminoglycan synthesis in rat articular cartilage
Autor: | T. A. H. Järvinen, T. Moilanen, T. L. N. Järvinen, E. Moilanen |
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Jazyk: | angličtina |
Rok vydání: | 1995 |
Předmět: | |
Zdroj: | Mediators of Inflammation, Vol 4, Iss 2, Pp 107-111 (1995) |
Druh dokumentu: | article |
ISSN: | 0962-9351 1466-1861 09629351 |
DOI: | 10.1155/S0962935195000184 |
Popis: | Interleek-1β (IL-1) is a key mediator of cartilage matrix degradation in osteoarthritis and rheumatoid arthritis. It was found that the IL-1-induced suppression of glycosaminoglycan (GAG) synthesis in rat articular cartilage occurred simultaneously with the accumulation of nitrite (a metabolite of nitric oxide (NO) in aqueous milieu) in the culture medium. NO-synthase inhibitors, L-NMMA and L-NIO, inhibited both these IL-1 effects. Dexamethasone suppressed GAG synthesis additively to IL-1, but did not alter nitrite accumulation. Three NO-donors (GEA 3175, SNAP and SIN-1) also had an inhibitory effect on cartilage GAG synthesis. Therefore, it is concluded that IL-1 induced suppression of GAG synthesis in rat articular cartilage is mediated by the production of NO. |
Databáze: | Directory of Open Access Journals |
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