Unconventional Gold-Catalyzed One-Pot/Multicomponent Synthesis of Propargylamines Starting from Benzyl Alcohols

Autor:	Stephany Zárate-Roldán, María Concepción Gimeno, Raquel P. Herrera
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	benzyl alcohols gold multicomponent one-pot propargylamine Chemical technology TP1-1185 Chemistry QD1-999
Zdroj:	Catalysts, Vol 11, Iss 4, p 513 (2021)
Druh dokumentu:	article
ISSN:	11040513 2073-4344
DOI:	10.3390/catal11040513
Popis:	A formal homogeneous gold-catalyzed A3-coupling, starting from benzyl alcohols, is reported for the straightforward synthesis of propargylamines. This is the first process where these highly valuable compounds have been synthesized, starting from the corresponding alcohols in a one-pot oxidation procedure using MnO2, followed by a HAuCl4·3H2O catalyzed multicomponent reaction. The final products are obtained with very good yields in short reaction times, which is of fundamental interest for the synthesis of pharmaceuticals. The usefulness and efficiency of our methodology is successfully compared against the same reaction starting from aldehydes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9d1e15a8804245ac8874f98c2b7129a4 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF