Direct Enzymatic Route for the Preparation of Novel Enantiomerically Enriched Hydroxylated β-Amino Ester Stereoisomers

Autor: Enikő Forró, László Schönstein, Loránd Kiss, Alberto Vega-Peñaloza, Eusebio Juaristi, Ferenc Fülöp
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Molecules, Vol 15, Iss 6, Pp 3998-4010 (2010)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules15063998
Popis: Enantiomerically enriched hydroxy-substituted b-amino esters have been synthesized through CAL-B-catalyzed enantioselective hydrolysis in organic media. Moderate to good enantiomeric excess values (ee ≥ 52%) were obtained when the CAL-B-catalyzed reactions were performed in t-BuOMe, at 60 ºC with 0.5 equiv. of added H2O as nucleophile.
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