Effect of Carbenoxolone on Inflammatory Cytokine Levels, Fasting Blood Sugar, and Histopathology of Pancreas on Experimental Autoimmune Diabetes in C57BL/6 Mice
| Autor: | Mehdi Rasouli, Yaser Jafari-khataylou, Javad Ashrafi-Helan |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 28, Iss 161, Pp 1-11 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: Destruction of insulin-producing beta cells by T cells causes type-1 diabetes (T1D). Carbenoxolone has cytoprotective and anti-inflammatory effects, and has been shown to be capable of suppressing Th17 cells that are effectively involved in the pathogenesis of type 1 diabetes, therefore, we studied the effect of Carbenoxolone on T1D in C57BL/6 mice. Materials and methods: Forty male C57BL/6 inbred strain mice were randomly divided into four groups and in three groups diabetes was induced by streptozotocin. A positive control group was considered and two other groups received 50 mg/kg/day i.p. carbenoxolone (7 and 5 doses). Then, on days 7 and 14 after the disease induction, fasting blood sugar (FBS) level, anti-inflammatory cytokines IL-1β, IL-6 and TNF-α, and pathological changes of the pancreas were studied during the course of the disease. Results: Carbenoxolone increased the levels of IL-1β, IL-6, TNF-α, and FBS. Also, it significantly increased infiltration of inflammatory cells into the pancreatic islets (P |
| Databáze: | Directory of Open Access Journals |
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