Urinary N‐terminal pro‐brain natriuretic peptide: prognostic value in patients with acute chest pain

Autor: Stefanie Reynen, Michael Schlossbauer, Ute Hubauer, Julian Hupf, Arno Mohr, Evelyn Orso, Markus Zimmermann, Andreas Luchner, Lars S. Maier, Stefan Wallner, Carsten G. Jungbauer
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: ESC Heart Failure, Vol 8, Iss 3, Pp 2293-2305 (2021)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.13332
Popis: Abstract Aims The objective of this study was to investigate the prognostic value of urinary N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) compared with plasma NT‐proBNP in patients presenting with acute chest pain in the emergency department. Methods and results We measured simultaneously plasma and urinary NT‐proBNP at admission in 301 patients with acute chest pain. In our cohort, 174 patients suffered from acute coronary syndrome (ACS). A follow‐up (median of 55 months) was performed regarding the endpoints all‐cause mortality and major adverse cardiac events (mortality, congestive heart failure, ACS with the necessity of a coronary intervention, and stroke). Fifty‐four patients died during follow‐up; 98 suffered from the combined endpoint. A significant and positive correlation of urinary and plasma NT‐proBNP was found (r = 0.87, P
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