Haemoglobin concentration and volume of intravenous fluids in septic shock in the ARISE trial

Autor: Matthew J. Maiden, Mark E. Finnis, Sandra Peake, Simon McRae, Anthony Delaney, Michael Bailey, Rinaldo Bellomo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Critical Care, Vol 22, Iss 1, Pp 1-8 (2018)
Druh dokumentu: article
ISSN: 1364-8535
DOI: 10.1186/s13054-018-2029-6
Popis: Abstract Background Intravenous fluids may contribute to lower haemoglobin levels in patients with septic shock. We sought to determine the relationship between the changes in haemoglobin concentration and the volume of intravenous fluids administered during resuscitation from septic shock. Methods We performed a retrospective cohort study of patients enrolled in the Australasian Resuscitation in Sepsis Evaluation (ARISE) trial who were not transfused red blood cells (N = 1275). We determined the relationship between haemoglobin concentration, its change over time and volume of intravenous fluids administered over 6, 24 and 72 h using univariate and multivariate analysis. Results Median (IQR) haemoglobin concentration at baseline was 133 (118–146) g/L and decreased to 115 (102–127) g/L within the first 6 h of resuscitation (P
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