HDL functionality in type 1 diabetes: enhancement of cholesterol efflux capacity in relationship with decreased HDL carbamylation after improvement of glycemic control

Autor:	Damien Denimal, Serge Monier, Isabelle Simoneau, Laurence Duvillard, Bruno Vergès, Benjamin Bouillet
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Carbamylation Cholesterol efflux HDL Type 1 diabetes Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-9 (2022)
Druh dokumentu:	article
ISSN:	1475-2840
DOI:	10.1186/s12933-022-01591-9
Popis:	Abstract Background Reduced cholesterol efflux capacity (CEC) of HDLs is likely to increase cardiovascular risk in type 1 diabetes (T1D). We aimed to assess whether improvement of glycemic control in T1D patients is associated with changes in CEC in relation with changes in carbamylation of HDLs. Methods In this open-label trial, 27 uncontrolled T1D patients were given a three-month standard medical intervention to improve glycemic control. HDL fraction was isolated from plasma, and CEC was measured on THP-1 macrophages. Carbamylation of HDLs was evaluated by an immunoassay. Control HDLs from healthy subjects were carbamylated in vitro with potassium cyanate. Results HbA1c decreased from 11.4% [10.2–12.9] (median [1st–3rd quartiles]) at baseline to 8.1% [6.6–9.0] after the three-month intervention (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9ce08ac5d39141728cb71242dd3f4f4a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.