| Autor: |
Yudit Oktanella, Handayu Untari, Dyah Kinasih Wuragil, Galuh Chandra Agustina, Dyah Ayu Oktavianie Pratama |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Open Veterinary Journal, Vol 13, Iss 8, Pp 1003-1011 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2226-4485 |
| DOI: |
10.5455/OVJ.2023.v13.i8.6 |
| Popis: |
Background: Polycystic ovary syndrome (PCOS) is an endocrine disease characterized by hyperandrogenism, hyperinsulinemia, followed by luteinizing hormone (LH) and follicle stimulating hormone (FSH) deficiency. PCOS conditions cause metabolic disorders that increase uric acid levels and malondialdehyde levels. Animal models of PCOS have been used extensively in research to study the pathogenesis, clinical characteristics and treatment of PCOS. Aim: This study aimed to identify the pathological mechanisms underlying renal dysfunction in PCOS by observing several parameters, including BUN, creatinine, uric acid, and renal MDA levels. Methods: This research was an experimental designed study using Wistar rat (Rattus norvegicus) as animal model of PCOS which were divided into three groups: negative control (CN) group (n=6), Testosterone propionate induction group (n=6), and estradiol valerate induction group (n=6). Results: According to statistical analysis it indicated that induction of TP and EV can increase blood uric acid levels in PCOS model rats (p [Open Vet J 2023; 13(8.000): 1003-1011] |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
