Synchronous Occurrence of Chronic Myeloid Leukemia and Mantle Cell Lymphoma

Autor: Prajwol Pathak, Ying Li, Brian Allen Gray, William Stratford May, Merry Jennifer Markham
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Case Reports in Hematology, Vol 2017 (2017)
Druh dokumentu: article
ISSN: 2090-6560
2090-6579
DOI: 10.1155/2017/7815095
Popis: Chronic myeloid leukemia (CML) and mantle cell lymphoma (MCL) are hematologic malignancies that originate from different oligopotent progenitor stem cells, namely, common myeloid and lymphoid progenitor cells, respectively. Although blastic transformation of CML can occur in the lymphoid lineage and CML has been related to non-Hodgkin lymphoma on transformation, to our knowledge, de novo and synchronous occurrence of CML and MCL has not been reported. Herein, we report the first case of synchronous CML and MCL in an otherwise healthy 38-year-old man. Potential etiologies and pathological relationships between the two malignancies are explored, including the possibility that the downstream effects of BCR-ABL may link it to an overexpression of cyclin D1, which is inherent to the etiology of MCL.
Databáze: Directory of Open Access Journals