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Feifei Yao,1 Jing Zhao,2 Yong Cui,3 Dandan Yu,4 Xiangyu Tang5 1Accreditation Department, Shekou People’s Hospital, Shenzhen City, Guangdong Province, 518067, People’s Republic of China; 2Department of Preventive Health, Daqing People’s Hospital, Daqing City, Heilongjiang Province, People’s Republic of China; 3Department of Oncology, Shekou People’s Hospital, Shenzhen City, Guangdong Province, 518067, People’s Republic of China; 4Jiangsu Center for Adverse Drug Reaction Monitoring, Nanjing, 210002, People’s Republic of China; 5Gastroenterology Department, Shekou People’s Hospital, Shenzhen City, Guangdong Province, 518067, People’s Republic of ChinaCorrespondence: Xiangyu TangGastroenterology Department, Shekou People’s Hospital, Shenzhen City, Guangdong Province, 518067, People’s Republic of ChinaEmail 347535969@qq.comPurpose: The role of sleep duration in the development of hypertension remains controversial. Little is known about the combined effects of nocturnal and daytime sleep. We assessed the association between total sleep duration and the development of hypertension in middle-aged and elderly Chinese adults.Patients and Methods: Data were obtained from 3 waves of China Health and Retirement Longitudinal Study surveys. Middle-aged and elderly Chinese initially without hypertension were followed biennially from 2011 to 2015. Sleep duration was self-reported. Hypertension was defined as a systolic and/or diastolic blood pressure ≥ 140/90 (mmHg), the current use of anti-hypertensive medications or self-reported hypertension.Results: Over 31,392 person-years of follow-up, 2682 of 10,176 participants developed hypertension. The multivariable adjusted hazard ratios (HR) (95% confidence intervals, 95% CI) for the development of hypertension between those with 0– 30 minutes and ≥ 30 minutes daytime sleep vs those without daytime sleep were 0.67 (0.58, 0.77), and 0.73 (0.59, 0.92), respectively. The protective role of longer periods of daytime sleep (> 30 minutes) varied between different subgroups. Compared with moderate nocturnal sleepers, long nocturnal sleepers (HR: 1.66, 95% CI=1.25– 2.21) had an increased risk of hypertension. Compared with moderate nocturnal sleepers without daytime sleep, HRs (95% CI) for hypertension were 0.52 (0.45, 0.59) for short nocturnal sleep plus short daytime sleep and 0.55 (0.49, 0.62) for short nocturnal sleep plus long daytime sleep. People with extremely short (HR: 1.34, 95% CI=1.22– 1.48) and long (HR: 1.28, 95% CI=1.13– 1.44) combined sleep periods had an increased risk of hypertension. Consistent results were also found in subgroups stratified by age and gender.Conclusion: Both extremely long and short total sleep periods were associated with an increased risk of hypertension. People with short or moderate nocturnal sleep durations, especially short nocturnal sleep duration, can benefit from habitual daytime sleep to prevent hypertension.Keywords: sleep duration, daytime sleep, hypertension, middle-aged and elderly |
