Oxaliplatin activates P53/miR‐34a/survivin axis in inhibiting the progression of gastric cancer cells

Autor: Qiang Guo, Xin‐Yuan Wang, Yan‐Chang Zhai, Yong‐Wei Dong, Qing‐Si He
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 12, Iss 9, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.70004
Popis: Abstract Introduction The purpose of this research was to determine how the P53/microRNA‐34a (miR‐34a)/survivin pathway contributes to oxaliplatin‐induced (L‐OHP) cell inhibition in gastric cancer. Methods The BGC‐823 gastric cancer cells were selected, and we examined their viability following treatment with L‐OHP at different concentrations and time periods. The expression levels of miR‐34a, P53, and survivin in the cells were determined. Results In the 12‐ and 24‐h groups, drug concentration of 15 μg/cm² (p
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje