| Autor: |
Carolina Mahuad, Otero Victoria, Korin Laura, Martinez Enriqueta, Warley Fernando, García Rivello Hernán, Cristaldo Nancy, Kohan Dana, Zerga Marta, Garate Gonzalo, Vicente Repáraz María de los Ángeles, Aizpurua Florencia, Rojas Bilbao Erica, Cerana Susana, Funes Maria Eugenia, Plaza Iliana, Foncuberta Cecilia, Vijnovich Baron Anahí, Cranco Santiago, Vitriu Adriana, Gomez Mariela, Lavalle Justina, Casali Claudia, Clavijo Manuela, Melillo Luciana, Cabral Lorenzo Maria Cecilia, Miroli Augusto, Fischman Laura, Pavlove Maximiliano, Miodosky Marcela, Cugliari Silvana |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical Hematology International, Vol 4, Iss 1-2, Pp 44-51 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0048 |
| DOI: |
10.1007/s44228-022-00008-4 |
| Popis: |
Abstract There are no data in Argentina on the response rates to first-line treatment of classical Hodgkin Lymphoma (cHL) outside clinical trials. A total of 498 patients from 7 public and private hospitals in Argentina were retrospectively examined. The median follow-up was 37.4 months (CI 95% 17.7–63.5). The median time from diagnosis to treatment was 22 days (IQR 14–42), which was significantly longer in public hospitals (49.3 (IC 95% 38.5–60.2) versus 32.5 (IC 95% 27–38); p = 0.0027). A total of 96.8% of patients were treated with ABVD.:84.3% achieved complete remission (CR) and 6.02% partial remission (PR), being the CR rate higher in private hospitals. End-of-treatment metabolic CR was achieved in 85.4% (n = 373). The interim PET scan was widely used in our cohort (70.5%; n = 351), but in only 23.3% (n = 116) was the treatment strategy response-adapted. The 5-year progression-free survival (PFS) was 76% (CI 95% 70–81). The 2 and 5-years-OS rates were 91% (CI 95% 88–94%) and 85% (CI 95% 80–89%), respectively. No differences in OS were found between public and private institutions (p = 0.27). This is one of the largest retrospective cHL cohorts reported. In Argentina ABVD is the chemotherapy regimen of choice and, although it is well tolerated, it is not exempt from toxicity. We showed that early initiation of treatment impacts the induction results. Although the use of PET scan is widespread, only a minority of patients was treated with respons- adapted strategies. The use of PET-guided treatment is strongly encouraged. |
| Databáze: |
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| Externí odkaz: |
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