Low-energy electrons transform the nimorazole molecule into a radiosensitiser

Autor: Rebecca Meißner, Jaroslav Kočišek, Linda Feketeová, Juraj Fedor, Michal Fárník, Paulo Limão-Vieira, Eugen Illenberger, Stephan Denifl
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10340-8
Popis: Radiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical anion, prerequisite for their accumulation in tumour cells.
Databáze: Directory of Open Access Journals