| Autor: |
Boban Stanojevic, Vladimir Saenko, Lidija Todorovic, Nina Petrovic, Dragan Nikolic, Vladan Zivaljevic, Ivan Paunovic, Masahiro Nakashima, Shunichi Yamashita, Radan Dzodic |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 9, Iss 12, p e114511 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0114511 |
| Popis: |
Alterations of the von Hippel-Lindau (VHL) tumor suppressor gene can cause different hereditary tumors associated with VHL syndrome, but the potential role of the VHL gene in papillary thyroid carcinoma (PTC) has not been characterized. This study set out to investigate the relationship of VHL expression level with clinicopathological features of PTC in an ethnically and geographically homogenous group of 264 patients from Serbia, for the first time. Multivariate logistic regression analysis showed a strong correlation between low level of VHL expression and advanced clinical stage (OR = 5.78, 95% CI 3.17-10.53, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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