Heat shock and other apoptosis-related proteins as therapeutic targets in prostate cancer

Autor:	Costantine Albany, Noah M Hahn
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	apatorsen apoptosis bcl-2 homologous antagonist-killer protein clusterin custirsen ganetespib heat-shock proteins prostatic neoplasms Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Asian Journal of Andrology, Vol 16, Iss 3, Pp 359-363 (2014)
Druh dokumentu:	article
ISSN:	1008-682X 1745-7262
DOI:	10.4103/1008-682X.126400
Popis:	Defects within apoptotic pathways have been implicated in prostate cancer (PCa) tumorigenesis, metastatic progression and treatment resistance. A hallmark of cancers is the ability to derail apoptosis by inhibiting the apoptotic signal, reducing the expression of apoptotic proteins and/or amplifying survival signals through increased production of antiapoptotic molecule. This review describes associations between heat shock proteins (HSPs) and the human androgen receptor (AR), the role of HSPs and other stress-induced proteins in PCa development and emerging strategies in targeting these protective proteins to treat PCa.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9c9197f8d0134a9b93e30057dce1de29 Zobrazit plný text záznamu View record in DOAJ