Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology
Autor: | Thor Ueland, Ingvild Hausberg, Trude Victoria Mørtberg, Tuva Børresdatter Dahl, Tøri Vigeland Lerum, Annika Michelsen, Trine Ranheim, Katerina Nezvalova Henriksen, Anne Ma Dyrhol-Riise, Pål André Holme, Trond Mogens Aaløkken, Ole Henning Skjønsberg, Andreas Barratt-Due, Maria Therese Ahlén, Pål Aukrust, Bente Halvorsen |
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Jazyk: | angličtina |
Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Platelets, Vol 33, Iss 4, Pp 640-644 (2022) |
Druh dokumentu: | article |
ISSN: | 0953-7104 1369-1635 09537104 |
DOI: | 10.1080/09537104.2022.2042238 |
Popis: | Thromboembolic events are frequent and associated with poor outcome in severe COVID-19 disease. Anti-PF4/polyanion antibodies are related to heparin-induced thrombocytopenia (HIT) and thrombus formation, but data on these antibodies in unselected COVID-19 populations are scarce. We assessed the presence of anti-PF4/polyanion antibodies in prospectively collected serum from an unselected cohort of hospitalized COVID-19 patients and evaluated if elevated levels could give prognostic information on ICU admission and respiratory failure (RF), were associated with markers of inflammation, endothelial activation, platelet activation, coagulation and fibrosis and were associated with long-term pulmonary CT changes. Five out of 65 patients had anti-PF4/polyanion reactivity with OD ≥0.200. These patients had more severe disease as reflected by ICU admission without any evidence of HIT. They also had signs of enhanced inflammation and fibrinogenesis as reflected by elevated ferritin and osteopontin, respectively, during the first 10 days of hospitalization. Increased ferritin and osteopontin persisted in these patients at 3 months follow-up, concomitant with pulmonary CT pathology. Our finding shows that the presence of anti-PF4/polyanion antibodies in unselected hospitalized COVID−19 patients was not related to HIT, but was associated with disease severity, inflammation, and pulmonary pathology after 3 months. |
Databáze: | Directory of Open Access Journals |
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