Rapid Detection of Methicillin-Resistant Staphylococcus aureus Directly from Blood for the Diagnosis of Bloodstream Infections: A Mini-Review

Autor: Anna Rita Buonomini, Elisabetta Riva, Giovanni Di Bonaventura, Giovanni Gherardi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Diagnostics, Vol 10, Iss 10, p 830 (2020)
Druh dokumentu: article
ISSN: 10100830
2075-4418
DOI: 10.3390/diagnostics10100830
Popis: Staphylococcus aureus represents a major human pathogen able to cause a number of infections, especially bloodstream infections (BSI). Clinical use of methicillin has led to the emergence of methicillin-resistant S. aureus (MRSA) and MRSA-BSI have been reported to be associated with high morbidity and mortality. Clinical diagnosis of BSI is based on the results from blood culture that, although considered the gold standard method, is time-consuming. For this reason, rapid diagnostic tests to identify the presence of methicillin-susceptible S. aureus (MSSA) and MRSA isolates directly in blood cultures are being used with increasing frequency to rapidly commence targeted antimicrobial therapy, also in the light of antimicrobial stewardship efforts. Here, we review and report the most common rapid non-molecular and molecular methods currently available to detect the presence of MRSA directly from blood.
Databáze: Directory of Open Access Journals
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