Synthesis and studies of the biological activity of novel pyrimido fused acridine derivatives

Autor:	Patel Bhavesh B., Patel Ranjan G., Patel Manish P.
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	6-bromoquinazolinone ullmann condensation pyrimido acridine antibacterialactivity antifungal activity Chemistry QD1-999
Zdroj:	Journal of the Serbian Chemical Society, Vol 71, Iss 10, Pp 1015-1023 (2006)
Druh dokumentu:	article
ISSN:	0352-5139 1820-7421
DOI:	10.2298/JSC0610015P
Popis:	Anthranilic acid was reacted with various substituted 6-bromoquinazolinones in the presence of Cu-powder and anhydrous potassium carbonate in DMF to give acid intermediates (Ullmann Type-II condensation). All these acids were then cyclized in phosphorus oxychloride to give 11-chloropyrimido[4,5-b]acridin-4(3H)-ones. All the synthesized compounds were identified by conventional methods (1H-NMR, IR, elemental analysis) and were screened for their antimicrobial activity on some bacterial and fungal cultures. The results were compared with standard bactericides and fungicides. All the synthesized compounds exhibited moderate antibacterial and antifungal activity. .
Databáze:	Directory of Open Access Journals
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