Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Autor: Mamona Nazir, Muhammad Saleem, Muhammad Imran Tousif, Muhammad Aijaz Anwar, Frank Surup, Iftikhar Ali, Daijie Wang, Nilufar Z. Mamadalieva, Elham Alshammari, Mohamed L. Ashour, Ahmed M. Ashour, Ishtiaq Ahmed, Elizbit, Ivan R. Green, Hidayat Hussain
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Biomolecules, Vol 11, Iss 7, p 957 (2021)
Druh dokumentu: article
ISSN: 2218-273X
DOI: 10.3390/biom11070957
Popis: Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.
Databáze: Directory of Open Access Journals
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