The Design of Minoxidil Microemulsion Formulation and the Effects of Ingredients on the Permeability of Rat Skin and Its Physicochemical Properties
| Autor: | Anayatollah Salimi, Eskandar Moghimipour, Ali Talebpour Jahromi, Saeed Mohammad Soleymani |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Mazandaran University of Medical Sciences, Vol 33, Iss 226, Pp 52-63 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1735-9260 1735-9279 |
| Popis: | Background and purpose: Minoxidil is one of the agents that can treat hair growth disorders, including alopecia, by increasing the anagen period. Due to the nature of minoxidil, the permeability of the drug to the skin surface is negligible. Therefore, the purpose of this study was to design and evaluate microemulsion formulations in order to increase skin permeability of minoxidil. Materials and methods: Microemulsions containing 2% minoxidil were prepared with an appropriate amount of oil phase, surfactant, and co-surfactant. The medicinal substance was dissolved in the oily phase. The physicochemical properties of the microemulsions, including particle size, viscosity, release, skin permeation through rat skin as well as the rate of drug permeation through rat skin, were evaluated using Franz cells. Results: The particle size of microemulsions was in the range of 5.45-10.4 nm, viscosity was 113.2-199.2 centipoise. This study showed that the parameters of drug release percentage in the second hour, drug release percentage in the 24th hour, viscosity and Dapp were significantly related to independent variables(P |
| Databáze: | Directory of Open Access Journals |
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