HTLV-1 and Adult T-Cell Leukemia: Insights into Viral Transformation of Cells 30 Years After Virus Discovery

Autor: Kuan-Teh Jeang
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Journal of the Formosan Medical Association, Vol 109, Iss 10, Pp 688-693 (2010)
Druh dokumentu: article
ISSN: 0929-6646
DOI: 10.1016/S0929-6646(10)60112-X
Popis: Human T-cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia, was the first human retrovirus to be isolated. It is now the 30th anniversary of the initial discovery of HTLV-1. This review discusses recent insights into the role of the HTLV-1 Tax oncoprotein in cellular proliferation and the abrogation of cellular checkpoints that lead to disease progression.
Databáze: Directory of Open Access Journals