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Joel Faintuch,1 Andre Dong Won Lee,2 Salomao Faintuch,3 Asher Mishaly,4 Francisco Juarez Almeida Karkow5 1Department of Gastroenterology, Sao Paulo University Medical School, Sao Paulo, SP, Brazil; 2Liver and Digestive Organs Transplantation Service, Hospital Das Clinicas, Sao Paulo, Brazil; 3Interventional Radiology, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 4Private Practice, Internal Medicine, Sao Paulo, Brazil; 5Department of Clinical Nutrition, Fatima Faculty of Nutrition, Caxias do Sul, RGS, BrazilCorrespondence: Joel Faintuch, Senior Professor of Gastroenterology, Hospital das Clínicas, Avenida Eneias C. Aguiar 255, 9th Floor, Rm 9077, Sao Paulo, SP, 05403-000, Brazil, Email faintuchj@gmail.comAbstract: As recently as 1990, short bowel syndrome in infants with less than 6 cm of remaining small intestine beyond the ligament of Treitz was defined as irreversibly lethal, and withholding further treatment was considered reasonable at that time (Reference deleted, Reviewer 2 item 1). Intestinal transplantation was already available, however not highly reliable. Nowadays transplantation is associated with long-term survival, even though indications are not expanding. On the contrary, they are shrinking, particularly for children as non-transplant handling. Surgical lengthening of the remaining gut, and more recently by enterohormone supplementation to stimulate diarrhea reversal and gut rehabilitation, is permitting encouraging rates of long-term survival. The purpose of this study was to review current non-surgical interventions aiming at parenteral nutrition weaning and intestinal failure reversal in the short bowel syndrome population, with emphasis on pediatric cases.Keywords: intestinal failure, gut rehabilitation, enterohormones, GLP-2, GLP-1, food supplements, short bowel syndrome |
