Advancing the understanding of venetoclax in t(11;14)-positive multiple myeloma: a comprehensive review of clinical evidence and future prospects
| Autor: | Abdullah AlZahrani, Nada Alsuhebany, Imran K. Tailor, Abdullah M. Alrajhi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: |
Venetoclax
t(11 14) multiple myeloma AML acute myeloid leukemia BCL2 B-cell lymphoma 2 CAR T-cell chimeric antigen receptor T-cell CLL chronic lymphocytic leukemia FDA Food and Drug Administration IC50 half maximal inhibitory concentration IL-6: interleukin 6 IMiD immune-modulators MM multiple myeloma ORR overall response rate PFS progression-free survival PI proteasome inhibitor RRMM relapsed/refractory multiple myeloma Diseases of the blood and blood-forming organs RC633-647.5 |
| Zdroj: | Hematology, Vol 29, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 16078454 1607-8454 |
| DOI: | 10.1080/16078454.2023.2296809 |
| Popis: | Venetoclax is a selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (BCL2), as a targeted therapy for multiple myeloma (MM) patients. It was initially approved by the United States Food and Drug Administration for the treatment of chronic lymphocytic leukemia in April 2016 and later for acute myeloid leukemia in October 2020. However, venetoclax is used as an off-label in a subset group of relapsed and refractory multiple myeloma (RRMM) patients with the presence of translocation t(11;14). Preclinical and clinical studies have highlighted the potential of venetoclax in the management of MM patients, with a specific focus on t(11;14) as a predictive biomarker for initiating venetoclax-based treatment. Later, several studies in RRMM patients that used venetoclax in combination with dexamethasone or/and proteasome inhibitors have shown promising results, in which management guidelines have included venetoclax as one of the options to treat MM patients. Hence, this review focuses on the use of venetoclax in RRMM, clinical efficacy, safety, dosing strategies, and predictive biomarkers for initiating venetoclax. Additionally, we discuss ongoing studies that are investigating different combination of venetoclax regimens in MM patients. |
| Databáze: | Directory of Open Access Journals |
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