Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells

Autor:	Monika Hreusova, Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Ivan Potočňák, Viktor Brabec, Jana Kasparkova
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Biotechnology TP248.13-248.65 Inorganic chemistry QD146-197
Zdroj:	Bioinorganic Chemistry and Applications, Vol 2022 (2022)
Druh dokumentu:	article
ISSN:	1687-479X
DOI:	10.1155/2022/3095749
Popis:	In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking selectivity to cancer cells compared to noncancerous human fibroblasts. The data reveal that the complex induces ferroptosis in rhabdomyosarcoma cells, likely due to interfering with iron metabolism. Importantly, it can kill both bulk and stem rhabdomyosarcoma cells. To the best of our knowledge, this is the first compound based on metal other than Fe capable of inducing ferroptosis in cancer cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/9c53d497024647a2992bcd5d8fe8e554 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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