A fast and highly efficient one-pot synthesis of novel isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones via Smiles rearrangement using task-specific ionic liquid [HMIm]BF4 as green solvent

Autor: Modugu Nagi Reddy, Pittala Praveen Kumar, Eligeti Rajanarendar
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Green Chemistry Letters and Reviews, Vol 10, Iss 1, Pp 48-53 (2017)
Druh dokumentu: article
ISSN: 1751-8253
1751-7192
17518253
DOI: 10.1080/17518253.2017.1285966
Popis: A facile and convenient procedure for the synthesis of isoxazolyl pyrido[2,3-b][1,4]oxazin-2(3H)-ones via Smiles rearrangement from isoxazole amine, chloroacetyl chloride and 2-chloro-3-hydroxypyridine using [HMIm]BF4 as task-specific ionic liquid has been described. The protocol proves to be efficient and environmentally benign in terms of high yields, eco-friendly solvent, ease of recovery, and reusability of reaction medium.
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