Usage of procalcitonin and sCD14-ST as diagnostic markers for postoperative spinal infection

Autor: Xi Zhu, Kaige Li, Jianping Zheng, Gen Xia, Feng Jiang, Huan Liu, Jiandang Shi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Orthopaedics and Traumatology, Vol 23, Iss 1, Pp 1-7 (2022)
Druh dokumentu: article
ISSN: 1590-9921
1590-9999
DOI: 10.1186/s10195-022-00644-9
Popis: Abstract Objective Identifying biomarkers for early diagnosis of postoperative spinal infection is essential to avoid complications after spine surgery. The presented study evaluated serum levels of procalcitonin (PCT), C-reactive protein (CRP), and soluble CD14 subtype (sCD14-ST) in patients who underwent spinal surgery to assess the diagnosis values of PCT and sCD14-ST. Methods Serum levels of PCT, CRP, and sCD14-ST were measured in 490 (289 male/201 female) patients who underwent spinal surgery (SS) before and 1 day after surgery. PCT and sCD14-ST levels of patients diagnosed with postoperative infection (PI) and patients diagnosed with postoperative non-infection (PN) were compared. Results Serum levels of PCT, CRP, and sCD14-ST were significantly increased after surgery (F = 58.393, P = 0.000). In patients diagnosed as having a PI, serum levels of PCT and sCD14-ST were positively correlated with each other (r = 0.90, P
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