Two New Picoline-Derived Meroterpenoids with Anti-Acetylcholinesterase Activity from Ascidian-Derived Fungus Amphichorda felina

Autor:	Minghua Jiang, Heng Guo, Qilin Wu, Siwen Yuan, Lan Liu
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	fungal meroterpenoid picoline Amphichorda felina anti-acetylcholinesterase activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 16, p 5076 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27165076
Popis:	Amphichoterpenoids D (1) and E (2), two new picoline-derived meroterpenoids with a rare 6/6/6 tricyclic pyrano[3,2-c]pyridinyl-γ-pyranone scaffold, were isolated from the ascidian-derived fungus Amphichorda felina SYSU-MS7908. Their structures, including the absolute configurations, were established by extensive spectroscopic methods (1D and 2D NMR and high-resolution mass spectrometry) and ECD calculations. Compounds 1 and 2 showed anti-acetylcholinesterase (anti-AChE) activities with IC50 values of 12.5 μM and 11.6 μM, respectively. The binding interactions between 1, 2, and AChE were investigated using molecular docking analyses.
Databáze:	Directory of Open Access Journals
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