Multicenter evaluation of the acid-fast bacillus smear, mycobacterial culture, Xpert MTB/RIF assay, and adenosine deaminase for the diagnosis of tuberculous peritonitis in China

Autor: Rongmei Liu, Jing Li, Yaoju Tan, Yuanyuan Shang, Yunxu Li, Biyi Su, Wei Shu, Yu Pang, Mengqiu Gao, Liping Ma
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Infectious Diseases, Vol 90, Iss , Pp 119-124 (2020)
Druh dokumentu: article
ISSN: 1201-9712
DOI: 10.1016/j.ijid.2019.10.036
Popis: Background: The aim of this study was to assess the validity of GeneXpert MTB/RIF (Xpert) and adenosine deaminase (ADA) in the diagnosis of tuberculous peritonitis (TBP). Methods: The laboratory results of peritoneal effusion (PE) specimens from patients with symptoms suggestive of TBP, attending three TB specialized hospitals between January 2016 and December 2018, were included retrospectively. Clinically diagnosed TBP was set as the gold standard to evaluate the performance of these methods. Results: In total, 191 individuals presenting with symptoms suggestive of TBP were included for analysis. The sensitivities of MGIT culture and Xpert were 17.2% and 18.3%, respectively. In addition, the TBP cases (69.8 ± 6.0 U/l) had higher amounts of ADA in their PE samples than the non-TBP cases (12.6 ± 1.6 U/l; p
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