| Autor: |
Ramin Tolouian, Audrey Tolouian, Farzaneh Dastan, Vida Farhangi, Payam Peymani, Sanam Saeifar, Oscar Felipe Borja Montes, Leila Mohmoodnia, Mohammadreza Khosravifarsani, Tella Sadighpour |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Nephropharmacology, Vol 12, Iss 1, Pp e10556-e10556 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2345-4202 |
| DOI: |
10.34172/npj.2022.10556 |
| Popis: |
Cisplatin is a first-line antitumor drug which is applied in the therapeutic field of numerous kinds of cancers. The main dose-dependent adverse effect of cisplatin is nephrotoxicity in approximately one-third of patients, who received this drug during their treatment. Oxidative stress is one of the most significant mechanisms in cisplatin nephrotoxicity. Cisplatin-induced oxidative stress stimulates apoptosis, inflammation, mitochondrial damage within cells, and endoplasmic reticulum (ER) stress. The administration of an antioxidant in this context could be a suitable approach for preventing of cisplatin nephrotoxicity. Antioxidants are categorized into four classes: dietary antioxidants, free radical scavengers, thiol-containing compounds, and iron chelators. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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