Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis

Autor: Yang Yang, Shudian Lin, Zhou Yang, Yanyan Huang, Feng Zhan
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Orthopaedic Surgery and Research, Vol 17, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 1749-799X
DOI: 10.1186/s13018-022-02939-3
Popis: Highlights 1. Circ_0001947 is abnormally upregulated in RA synovial tissues and RA-FLSs. 2. Circ_0001947 silencing inhibits cell proliferation, invasion, migration and inflammatory response and induces apoptosis in RA-FLSs. 3. Circ_0001947 sponges miR-671-5p, which directly interacts with STAT3. 4. Circ_0001947 regulates RA-FLS progression via miR-671-5p/STAT3 axis.
Databáze: Directory of Open Access Journals
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