Effects of Dimenhydrinate and Ondansetron Used in Pregnant Rats on Postnatal Morphometric Development
| Autor: | Kadir Desdicioğlu, Neslihan Cankara, Emine Hilal Evcil, Raziye Desdicioğlu, Mehmet Ali Malas |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Balkan Medical Journal, Vol 28, Iss 01, Pp 1-9 (2011) |
| Druh dokumentu: | article |
| ISSN: | 2146-3123 2146-3131 |
| Popis: | Objective: To determine the effects of dimenhydrinate (DMH) and ondansetron, used as antiemetics during pregnancy, on the length of gestation, maternal weight gain during gestation and postnatal morphometric parameters of pups.Material and Methods: Thirty female Wistar albino rats were used in the study. Three groups comprising 10 rats each were studied: Group 1: control group; Group 2: DMH group; and Group 3: ondansetron group. Rats were impregnated and administered 115 mg/kg/day intramuscular, DMH group, or 10 mg/kg/day intraperitoneal, ondansetron group. The parameters pertaining to the cranium, thorax and limbs were measured between newborn and adulthood.Results: The increase in mean morphometric parameters during the postnatal period in the DMH group was less than the control group,whereas that in the ondansetron group exceeded the controls (p |
| Databáze: | Directory of Open Access Journals |
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