Autor: |
Tang-Wei Chuang, Chao-Hung Hung, Shun-Chen Huang, Chuan-Mo Lee |
Jazyk: |
angličtina |
Rok vydání: |
2007 |
Předmět: |
|
Zdroj: |
Journal of the Formosan Medical Association, Vol 106, Iss 10, Pp 869-873 (2007) |
Druh dokumentu: |
article |
ISSN: |
0929-6646 |
DOI: |
10.1016/S0929-6646(08)60054-6 |
Popis: |
We present the case of a 22-year-old male with chronic hepatitis B virus (HBV) infection, who developed nephrotic syndrome and had complete remission after lamivudine monotherapy. Renal biopsy showed membranous glomerulopathy, and the serum titer of HBV DNA increased to 1,130,000 copies/mL. As symptomatic therapy with angiotensin converting enzyme inhibitors did not improve the nephrotic syndrome, lamivudine 100 mg per day was started. His alanine aminotransferase level normalized 2 months after treatment, then hepatitis B e antigen seroconversion developed and serum HBV DNA became undetectable. His proteinuria improved subsequently and his leg edema disappeared completely 6 months after treatment. Neither hepatitis nor nephrotic syndrome had relapsed by month 13 when he came for follow-up. This suggests that lamivudine monotherapy may induce and maintain complete remission of membranous glomerulopathy associated with hepatitis B. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
|