| Autor: |
Aleksandra Hecel, Małgorzata Ostrowska, Kamila Stokowa-Sołtys, Joanna Wątły, Dorota Dudek, Adriana Miller, Sławomir Potocki, Agnieszka Matera-Witkiewicz, Alicia Dominguez-Martin, Henryk Kozłowski, Magdalena Rowińska-Żyrek |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Pharmaceuticals, Vol 13, Iss 9, p 228 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1424-8247 |
| DOI: |
10.3390/ph13090228 |
| Popis: |
Zn(II) is an inhibitor of SARS-CoV-2′s RNA-dependent RNA polymerase, and chloroquine and hydroxychloroquine are Zn(II) ionophores–this statement gives a curious mind a lot to think about. We show results of the first clinical trials on chloroquine (CQ) and hydroxychloroquine (HCQ) in the treatment of COVID-19, as well as earlier reports on the anticoronaviral properties of these two compounds and of Zn(II) itself. Other FDA-approved Zn(II) ionophores are given a decent amount of attention and are thought of as possible COVID-19 therapeutics. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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