| Autor: |
Xu-yang Wang, Pei-yuan Gu, Shi-wen Chen, Wen-wei Gao, Heng-li Tian, Xiang-he Lu, Wei-ming Zheng, Qi-chuan Zhuge, Wei-xing Hu |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Neural Regeneration Research, Vol 10, Iss 11, Pp 1865-1868 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1673-5374 |
| DOI: |
10.4103/1673-5374.170318 |
| Popis: |
In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy. The left L 1-5 and L 7 -S 2 dorsal root ganglia in adult cats were exposed and removed, preserving the L 6 dorsal root ganglia. Neurotrophin-3 was mainly expressed in large neurons in the dorsal root ganglia and in some neurons in spinal lamina II. Two months after rhizotomy, the number of neurotrophin-3-positive neurons in the spared dorsal root ganglia and the density of neurite sprouts emerging from these ganglia were increased. Intraperitoneal injection of an antibody against neurotrophin-3 decreased the density of neurite sprouts. These findings suggest that endogenous neurotrophin-3 is involved in spinal cord plasticity and regeneration, and that it promotes axonal sprouting from the dorsal root ganglia after spinal cord dorsal root rhizotomy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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