Association between serum uric acid‐to‐high‐density lipoprotein cholesterol ratio and insulin resistance in patients with type 2 diabetes mellitus

Autor: Xinhe Zhou, Jing Xu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Diabetes Investigation, Vol 15, Iss 1, Pp 113-120 (2024)
Druh dokumentu: article
ISSN: 2040-1124
2040-1116
DOI: 10.1111/jdi.14086
Popis: ABSTRACT Introduction Previous studies have shown that the serum uric acid‐to‐high‐density lipoprotein cholesterol ratio (UHR) is related to metabolic syndrome. However, no existing study has examined the relationship between UHR and insulin resistance (IR). Therefore, this study aims to explore the association between the UHR and IR in patients with type 2 diabetes mellitus (T2DM). Methods Patients with type 2 diabetes mellitus (1,532 males and 1,013 females) were enrolled. Insulin resistance was measured by homeostatic model assessment of insulin resistance (HOMA‐IR) and was defined as HOMI‐IR ≥ 2.69. Pearson correlation, multiple logistic regression, ROC analysis, and subgroup analysis were used to evaluate the association between UHR and IR. Results UHR was associated with HOMA‐IR in patients with type 2 diabetes mellitus (pearson's correlation coefficient = 0.274 in males and 0.337 in females, P
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