Persistent idiopathic prolactin elevation merits macroprolactin estimation: A case report and review of literature
| Autor: | Krishnaprabha Gautam, Kripa Elizabeth Cherian, Arun Jose, T K Aleyamma, Nitin Kapoor, Thomas Vizhalil Paul |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Human Reproductive Sciences, Vol 14, Iss 2, Pp 206-210 (2021) |
| Druh dokumentu: | article |
| ISSN: | 0974-1208 1998-4766 |
| DOI: | 10.4103/jhrs.jhrs_168_20 |
| Popis: | The prevalence of hyperprolactinemia ranges from about 0.4% in an unselected adult population to as high as 9%–17% in women with reproductive disorders. It may cause infertility in about 11% of the oligospermic males. Rarely, the cause of persistently elevated prolactin remains obscure even after thorough work up. Macroprolactinemia is biologically inactive, high-molecular-weight form of prolactin resulting from its binding to immunoglobulin G, causing a decrease in its clearance. We report the case of a 35-year-old female, detected to have hyperprolactinemia on multiple tests, during routine work up for primary infertility. Secondary causes for the same were ruled out. A magnetic resonance imaging (MRI) of the brain excluded a prolactinoma. This prompted an estimation of prolactin levels after polyethylene glycol precipitation which showed a decrease to 5.58 ng/mL, with |
| Databáze: | Directory of Open Access Journals |
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