Potential Drug-Drug Interactions in Critically Ill Medical Patients: A Cross-Sectional Study
| Autor: | Elham Hosseini, Lida Shojaei, Hassanali Karimpour, Foroud Shahbazi |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Pharmaceutical Care, Vol 6, Iss 3-4 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2322-4630 2322-4509 |
| Popis: | Background: Drug interaction commonly occurred in critically ill patients and may increase hospital lengths of stay and total cost. The aim of the present study is to evaluate potential drug-drug interaction in critically ill patients. Methods: In this cross-sectional study, medical records of critically ill patients admitted to the 16-bed intensive-care units of a teaching hospital were assessed according to the Micromedex® drug interaction and drug interaction fact®. The identified drug-drug interactions were categorized by level of severity. The agreement between two resources was assessed. Results: Our survey found 915 and 564 paired DDIs according to the Micromedex® and drug interaction fact®, respectively, amongst 120 patients. The prevalence of potential DDIs (pDDIs) was 87.7% and 91.7% with drug interaction Fact® and Micromedex®, respectively. Approximately, 80% of recruited patients, had at least three pDDIs based on Micromedex®. A significant moderate agreement between two drug interaction compendia was reported. (kappa= 0.41, 95% CI: 0.167-0.649, p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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