Clinical factors and outcomes associated with immune non-response among virally suppressed adults with HIV from Africa and the United States

Autor: Adi Noiman, Allahna Esber, Xun Wang, Emmanuel Bahemana, Yakubu Adamu, Michael Iroezindu, Francis Kiweewa, Jonah Maswai, John Owuoth, Lucas Maganga, Anuradha Ganesan, Ryan C. Maves, Tahaniyat Lalani, Rhonda E. Colombo, Jason F. Okulicz, Christina Polyak, Trevor A. Crowell, Julie A. Ake, Brian K. Agan
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-04866-z
Popis: Abstract A significant minority of people living with HIV (PLWH) achieve viral suppression (VS) on antiretroviral therapy (ART) but do not regain healthy CD4 counts. Clinical factors affecting this immune non-response (INR) and its effect on incident serious non-AIDS events (SNAEs) have been challenging to understand due to confounders that are difficult to control in many study settings. The U.S. Military HIV Natural History Study (NHS) and African Cohort Study (AFRICOS). PLWH with sustained VS (
Databáze: Directory of Open Access Journals
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