Analysis of potential protective effects of caffeic acid phenethyl ester against gentamicin ototoxicity: An experimental study
| Autor: | Fuat Aydemir, Cagatay Han Ulku, Cigdem Elmas, Cemile Merve Seymen |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Iranian Journal of Basic Medical Sciences, Vol 25, Iss 1, Pp 121-125 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2008-3866 2008-3874 |
| DOI: | 10.22038/ijbms.2022.60794.13467 |
| Popis: | Objective(s): In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model.Materials and Methods: Thirty Wistar albino rats were divided into 3 groups. Group I was selected as the control group. Gentamicin was administered intraperitoneally in group II, gentamicin and CAPE in group III. Audiological assessment was performed by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) measurements before and after treatment of each group. At the end of the study all rats were decapitated, cochlea was removed and electron microscopic examination was performed. Results: In group II post-treatment DPOAE levels were found to be lower than pretreatment DPOAE levels (P0.05). Except for Group I, ABR thresholds increased after the procedure and this increase was statistically significant (P |
| Databáze: | Directory of Open Access Journals |
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